中医药调控炎症反应信号通路防治肺动脉高压的研究进展

Research progress on the regulation of inflammatory reaction signaling pathways by traditional Chinese medicine to prevent pulmonary hypertension

关键词:  中医药  肺动脉高压  炎症反应  信号通路

Key words:  traditional Chinese medicine  pulmonary hypertension  inflammatory reaction  signaling pathway

摘要:

肺动脉高压（PH）是由多种病因引起肺血管阻力和肺动脉压力升高的临床综合征，可以引起右心室后负荷增加，导致右心衰竭甚至死亡。PH发病机制包括炎症反应、血管活性物质失衡、能量代谢异常等，其中炎症反应广泛参与PH的发生与发展，被认为是治疗PH的潜在关键靶标。近年来，中医药在PH的治疗中显示出明显疗效，相关多成分、多通路、多靶点的机制研究广泛开展。文章综述了中医药干预的核转录因子-κB（NF-κB）、丝裂原活化蛋白激酶（MAPK）、NOD样受体蛋白3（NLRP3）及Janus激酶（JAK）/信号转导和转录激活因子（STAT）信号通路4条炎症反应信号通路的研究进展，为后续中医药防治PH临床与基础研究的开展提供参考。

Abstract:

Pulmonary hypertension（PH） is a clinical syndrome of elevated pulmonary vascular resistance and pulmonary artery pressure caused by a variety of etiological factors，which can lead to increased right ventricular afterload，resulting in right heart failure or even death. The pathogenesis of PH includes inflammatory response，imbalance of vasoactive substances，and abnormal energy metabolism，etc. Inflammatory response is widely involved in the development of PH，which is considered to be a potential key target for the treatment of PH. In recent years，traditional Chinese medicine（TCM） has shown significant efficacy in the treatment of PH，and related multi-component，multi-pathway and multi-target mechanism studies have been widely carried out. This article reviews the progress of research on four inflammatory response signaling pathways，including the NF-κB signaling pathway，MAPK signaling pathway，NLRP3 signaling pathway，and the JAK/STAT signaling pathway，to provide references for the subsequent clinical and basic studies on TCM in the prevention and treatment of PH.