Notch信号通路在心血管疾病中的作用及中药调控机制研究

The Role of the Notch Signaling Pathway in Cardiovascular Diseases and the Regulatory Mechanisms of Traditional Chinese Medicine

关键词:  Notch信号通路  心肌梗死  动脉粥样硬化  信号调控

Key words:  Notch signaling pathway  myocardial infarct  atherosclerosis  signal regulation

摘要:

Notch信号通路作为经典且高度保守的信号传导途径，调节细胞生长、分化、发育及组织修复和器官形成，心脏的发育、成长及稳态受Notch信号通路调控，心脏疾病的发生发展和防治与Notch信号也有着密不可分的关系。中医药可通过调控Notch信号治疗多种心血管疾病，在临床心血管疾病治疗中有巨大的研究潜力。文章针对Notch信号通路与各种心血管疾病之间的关系，及中药调控Notch信号治疗心血管疾病进行阐述，为中医药防治心血管疾病提供新的理论依据。

Abstract:

The Notch signaling pathway, is a highly conserved and essential mechanism in regulating cell growth, differentiation, development, tissue repair, and organ formation. Its function has been intrinsically linked to the development, growth, and homeostasis of the heart. Nonetheless, several research has shown that dysfunction of the Notch pathway is implicated in the development and progression of some cardiovascular diseases. Traditional Chinese medicine(TCM) has shown promise in treating cardiovascular diseases by regulating factors involved in the pathways that underscore the pathogenesis of the disease. This article summarizes the relationship between the Notch signaling pathway and various cardiovascular diseases while highlighting the regulatory effects of traditional Chinese medicine on the Notch signaling in treating these conditions. By carefully outlining these interactions, we seek to present a concise mechanism of action of traditional Chinese medicine in preventing and treating cardiovascular diseases.