肠道菌群代谢物与中药干预在结直肠癌防治中的作用研究

Research progress on the influence of traditional Chinese medicine on gut microbiota metabolites on colorectal cancer

关键词:  结直肠癌  中药  肠道菌群  肠道菌群代谢物  分子机制

Key words:  colorectal cancer  traditional Chinese medicine  gut microbiota  gut microbiota metabolites  molecular mechanism

摘要:

结直肠癌作为常见的消化系统恶性肿瘤，备受关注。近年来，研究发现肠道菌群平衡对健康至关重要，菌群失调与结直肠癌等疾病密切相关。肠道菌群代谢产物，如短链脂肪酸、胆汁酸和吲哚衍生物等，能调节肠道微环境，影响炎症和细胞凋亡，在结直肠癌发生和进展中起重要作用。中药通过调节肠道菌群及其代谢产物，成为结直肠癌研究热点，显示出预防和治疗潜力。未来研究应继续探索其具体机制，为结直肠癌防治策略提供科学依据。

Abstract:

Colorectal cancer(CRC), a prevalent malignancy of the digestive system, has garnered significant attention in recent years. Emerging evidence highlights the critical role of gut microbiota homeostasis in maintaining health, with dysbiosis closely linked to diseases such as CRC. Metabolites derived from gut microbiota, including short-chain fatty acids, bile acids, and indole derivatives, regulate the intestinal microenvironment, modulate inflammation, and influence apoptosis, playing pivotal roles in CRC onset and progression. Traditional Chinese medicine(TCM) has become a focal point of CRC research due to its potential to regulate gut microbiota and their metabolites, demonstrating promise in prevention and therapy. Future studies should elucidate the underlying mechanisms of TCM to provide a scientific basis for developing effective CRC management strategies.