古今附子临床安全性用药研究进展

Research progress review on ancient and modern clinical medication safety studies of Aconiti Lateralis Radix Praeparata

关键词:  附子  临床应用  减毒  安全性

Key words:  Aconiti Lateralis Radix Praeparata  Clinical application  Detoxification  Safety

摘要:

附子的安全性问题，自古以来便是临床应用中的一个焦点与难题。历代医家对于附子的毒性持有不同的见解，而其误用往往会导致严重的不良后果。文章深入探讨了附子在临床应用中的安全性问题，从古籍记载、临床实践经验、毒性成分分析以及增效减毒策略4个维度出发，全面细致地分析了附子的毒性及其在临床应用中的风险。旨在为临床医生提供安全合理使用附子的参考框架，以期减少误用附子的风险，确保用药安全。

Abstract:

The safety of Aconiti Lateralis Radix Praeparata(Fuzi) has long been a focal and challenging issue in clinical practice. Historically, medical practitioners have held divergent perspectives on its toxicity, and its misuse often leads to severe adverse outcomes. This study investigates the safety concerns of Fuzi in clinical application through a multidimensional approach, encompassing ancient textual records, clinical practical experience, analysis of toxic components, and strategies for enhancing efficacy and reducing toxicity. By systematically examining the inherent risks and toxicological profile of Fuzi, this research provides a comprehensive and detailed evaluation of its clinical applicability. Through rigorous scientific methods, the paper establishes a reference framework to guide clinicians in the safe and rational use of Fuzi, aiming to mitigate risks associated with improper administration and ensure medication safety.