M6A修饰在动脉粥样硬化中的作用及中医药干预研究进展

Role of m6A modification in atherosclerosis and the research progress of traditional Chinese medicine intervention

关键词:  m6A甲基化  动脉粥样硬化  中医药治疗  作用机制

Key words:  m6A methylation  atherosclerosis  Chinese medicine  mechanism of action

摘要:

心血管疾病的高发率目前还是关乎人民健康的最主要问题，严重影响患者的生活质量。动脉粥样硬化是心血管疾病的基础病理因素之一。N6-甲基腺苷（N6-methyladenosine，m6A）甲基化修饰作为真核细胞中RNA最常见的表观遗传修饰，近年来发现在动脉粥样硬化的发生发展中发挥关键作用。研究表明，m6A可以通过调控炎症反应、脂质代谢紊乱等过程，参与动脉粥样硬化的病理进展。中医药在动脉粥样硬化（atherosclerosis，AS）防治中展现出多靶点调控优势，部分中药活性成分及复方制剂可通过调节m6A相关酶表达或RNA修饰水平，干预AS相关信号通路。然而，目前中医药干预m6A的研究尚处于起步阶段，作用机制及药效物质基础需结合多种技术深入解析。未来需整合表观遗传学与中医药理论，推动AS精准治疗策略的发展。

Abstract:

The high prevalence of cardiovascular diseases（CVDs）is still the most important health concern of the people，which seriously affects the quality of life of patients. Atherosclerosis is one of the underlying pathological factors of cardiovascular diseases. N6-methyladenosine（m6A）methylation modification，as the most common epigenetic modification of RNA in eukaryotic cells，has been found to play a key role in the development of atherosclerosis in recent years. Studies have shown that m6A can participate in the pathological progression of atherosclerosis by regulating inflammatory responses，lipid metabolism disorders and other processes. Traditional Chinese medicine（TCM）has demonstrated the advantage of multi-target regulation in the prevention and treatment of atherosclerosis（AS），and some of the active ingredients and compound preparations of TCM can intervene in AS- related signaling pathways by regulating the expression of m6A-related enzymes or RNA modification levels. However，the study of m6A intervention by TCM is still in the initial stage，and the mechanism of action and the material basis of pharmacological effect need to be analyzed in depth by combining various techniques. In the future，it is necessary to integrate the theories of epigenetics and traditional Chinese medicine to promote the development of precise therapeutic strategies for AS.