| 摘要: |
| [目的] 研究虫草素抗炎作用及机制。[方法] 通过二甲苯致小鼠耳肿胀实验研究虫草素不同剂量(50、100、200 mg/kg)对耳肿胀的抑制作用,在细胞水平研究虫草素(12.5、25、50 μmol/L)对诱导型一氧化氮合酶(iNOS)和环氧酶-2(COX-2)表达和一氧化氮(NO)和前列腺素E2(PGE2)产生的影响。[结果] 虫草素(200 mg/kg)能够抑制二甲苯致小鼠耳肿胀(P<0.05)和耳片中一氧化氮(NO)和前列腺素E2(PGE2)的产生(P<0.05)。在细胞水平虫草素(25、50 μmol/L)能够抑制诱导型一氧化氮合酶(iNOS)和环氧酶-2(COX-2)表达(P<0.05),一氧化氮(NO)和前列腺素E2(PGE2)的产生(P<0.05)。[结论] 虫草素具有抗炎作用。 |
| 关键词: 虫草素 抗炎 一氧化氮 前列腺素E2 诱导型一氧化氮合酶 环氧酶-2 |
| DOI：10.11656/j.issn.1672-1519.2016.05.12 |
| 分类号: |
| 基金项目:国家自然科学基金项目(81470016),深圳市科技研发基金项目(NJCYJ20140414145007216)。 |
|
| Anti-inflammatory effect and mechanism study of Cordycepin |
|
LI Hui1, SUN Jia-yu2, LIAO Kang-han1, WANG Zhe3, SHAN Ai-yun2
|
|
1.Shenzhen Nanshan District Hospital, Shengzhen 518067, China;2.Shenzhen Futian District Traditional Chinese Medicine Hospital, Shengzhen 518033, China;3.Central South University Xiangya School of Medicine, Changsha 410013, China
|
| Abstract: |
| [Objective] To study the anti-inflammatory effect of Cordycepin. [Methods] By Xylene induce ear swelling test in mice, the inhibition of Cordycepin (50, 100, 200 mg/kg)was evaluated for ear swelling. At the cellular level, the effect of Cordycepin(12.5, 25, 50 μmol/L)was evaluated for iNOS and COX-2 expression, NO and PGE2 production. [Results] Cordycepin(200 mg/kg)inhibited ear swelling of mice (P<0.05), NO and PGE2 production in mouse ear piece(P<0.05). At the cellular model, Cordycepin (25, 50 μmol/L)inhibited iNOS and COX-2 expression(P<0.05),NO and PGE2 production(P<0.05). [Conclusion] Cordycepin have anti-inflammatory effect. |
| Key words: Cordycepin anti-inflammation NO PGE2 iNOS COX-2 |
