痛风和高尿酸血症动物模型研究进展及代谢通路分析

Overview of animal models of gout and hyperuricemia and metabolic pathway analysis

关键词:  痛风  痹症  高尿酸血症  动物模型  代谢通路

Key words:  gout  arthragia syndrome  hyperuricemia  animal model  metabolic pathway

摘要:

痛风属于中医"痹症"，是嘌呤代谢障碍引起的血尿酸增高的一种慢性代谢性疾病，主要表现为高尿酸血症、痛风性肾病、痛风性关节炎等，其发病率呈上升趋势，严重影响人类生命健康。动物模型的建立和选择对于阐明痛风发病机制、寻找有效防治药物至关重要。通过不同方法诱导而成的痛风和高尿酸血症动物模型主要有直接补充尿酸或尿酸前体法诱导模型、氧嗪酸钾诱导高尿酸血症模型、真菌产物诱导高尿酸血症模型和药物诱导高尿酸血症模型。文章对痛风和高尿酸血症动物模型进行了系统的总结，借助代谢组学Pathway分析方法，比较动物模型组与痛风和高尿酸血症患者代谢通路的异同，为进一步研究痛风和高尿酸血症相关代谢通路及发病机制提供参考。

Abstract:

Arthragia syndrome is a chronic metabolic disease caused by elevated levels of uric acid in the blood due to purine metabolic disturbance that can present in multiple ways,such as hyperuricemia,gouty kidney disease,gouty arthritis and so on. The trend of gout incidence rate shows a recent increase. In order to elucidate the pathogenesis of gout and find out more effective drugs,the establishment and selection of experimental animal models are critical. Based on different methods,experimental animal models of gout and hyperuricemia can be established by sufficient uric acid or its precursor-induced gout model,potassium oxonate-,fungal products-,drug-induced hyperuricemia. The paper systematically summarized the methods of animal models of gout and hyperuricemia. The metabolic pathways of induced model groups can be compared to clinical hyperuricemia patients',by means of metabolomics analysis,which provides references for further researches on metabolic pathways and pathogenesis of gout and hyperuricemia.