| 摘要: |
| [目的] 探讨急性心肌梗死（AMI）血瘀证患者纤维蛋白原（FIB）、超敏C反应蛋白（hs-CRP）及补体系统表达变化。[方法] 检测72例AMI患者血瘀证、非血瘀证及33例健康对照者的血清样本中hs-CRP、FIB及补体C3、C4、C5b-9的表达变化，并比较以上指标之间及其与血瘀证的相关性。[结果] AMI患者的血清FIB、C3、C4、C5b-9及 hs-CRP表达均较对照组显着升高，且血瘀证组高于非血瘀证组；血瘀证与hs-CRP、FIB、D-2聚体水平呈正相关（r=0.239、r=0.402、r=0.199,P<0.05）;GRACE评分与血瘀证、hs-CRP水平呈正相关（r=0.309、r=0.376,P<0.05）.[结论] AMI患者具有一定程度炎性反应和补体激活，而在血瘀证中表达更为明显；血瘀证为AMI患者中的较高危者，早期辨证治疗可降低急性心血管事件的发生风险。 |
| 关键词: 急性心肌梗死 血瘀证 纤维蛋白原 超敏C反应蛋白 补体系统 |
| DOI：10.11656/j.issn.1673-9043.2016.04.05 |
| 分类号: |
| 基金项目:天津市卫生局科技基金项目（2014KZ052）。 |
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| The expressions and changes of fibrinogen hypersensitive C reactive protein and the complement system in patients of acute myocardial infarction and blood stasis syndrome |
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SHAO Ai-hong1,2, QI Xin2, JIA Wen-jun2, LI Qi2
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1.Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China;2.Internal Medicine-Cardiovascular Department, Tianjin People's Hospital, Tianjin 300191, China
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| Abstract: |
| [Objective] To investigate the expression of fibrinogen hypersensitive C-reactive protein, and complement system in the patients with acute myocardial infarction and blood stasis syndrome. [Methods] Detect the levels of fibrinogen, hypersensitive C reactive protein, and the complement system including C3, C4, C5b-9 for 72 patients with acute myocardial infarction including blood stasis and non-blood stasis syndrome, the same as 33 healthy control group, and analyse the correlation between the indexes above and blood stasis syndrome. [Results] Comparing with the control group, levels of fibrinogen, hypersensitive C reactive protein, and the complement system including C3, C4, C5b-9 in patients of AMI were significantly higher than those in control group, and levels in blood stasis syndrome group were higher than in non-blood stasis syndrome group;there were positive correlation between blood stasis and hs-CRP, FIB and D-dimer(r=0.239, r=0.402, r=0.199, P<0.05); there were positive correlation between score of GRACE and the levels of blood stasis syndrome, hs-CRP(r=0.309, r=0.376, P<0.05). [Conclusion] There are certain degree of inflammatory reaction and high coagulation state in patients with acute myocardial infarction, which express more obviously in blood stasis group;there are positive correlation between blood stasis group hs-CRP, FIB and D-dimer;early dialectical therapy for blood stasis syndrome in patients of AMI with a high risk can reduce the risk of the occurrence of acute cardiovascular events. |
| Key words: acute myocardial infarction blood stasis syndrome fibrinogen hypersensitive C reactive protein complement system |
