| 摘要: |
| [目的] 对Icariin/HAP纳米凝胶剂处方进行优化并考察其体外释放特性。[方法] 物理吸附法制备Icariin/HAP纳米混悬液，研和法制备Icariin/HAP纳米凝胶，采用正交设计对处方进行优化，透析法测定Icariin/HAP纳米凝胶中药物的释放。[结果] Icariin/HAP纳米凝胶优选处方为卡波姆浓度为1%,三乙醇胺用量为1.5%,丙二醇用量为5%.Icariin/HAP纳米凝胶剂、Icariin凝胶剂和Icariin溶液体外释放均符合一级模型和Weibull模型。[结论] 以卡波姆为基质制备Icariin/HAP纳米凝胶，处方简单，质量稳定，可提高Icariin/HAP纳米混悬液的稳定性。 |
| 关键词: Icariin 纳米HAP 正交设计 体外释放 |
| DOI：10.11656/j.issn.1673-9043.2016.04.11 |
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| 基金项目: |
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| Study on formulation optimization and in vitro release of Icariin/HAP nanoparticle gel |
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LIU Meng-meng1, JING Hui-xin1, BAI Run1, WANG Yang1,2
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1.College of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China;2.Department of Experimental Teaching, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
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| Abstract: |
| [Objective] To optimize the prescription of Icariin/HAP nanoparticle gel and evaluate its in vitro release characteristics. [Methods] The Icariin/HAP nanoparticle suspension liquid was prepared by physical adsorption, Icariin / HAP nanoparticle gel was prepared by grinding method, orthogonal design was used to optimize prescription, dialysis method was developed for the determination of Icariin/HAP nanoparticle gel in the drug release. [Results] The optimum gel was made by carbomer 1%, triethanolamine 1.5%, Propylene glycol 5%, the in vitro release curve of Icariin/HAP nanoparticle gel, Icariin gel and Icariin solution were fitted with pseudo-first-order model and Weibull model. [Conclusion] Using carbomer to make Icariin/HAP nanoparticle gel is simple and stable, can improve the stability of Icariin/HAP nanoparticle suspension liquid. |
| Key words: Icariin nano HAP orthogonal design in vitro release |
