杞黄颗粒对肝肾阴虚型年龄相关性黄斑变性临床证候的影响

Effects of Qihuang Particles on clinical syndrome in live-kidney deficiency of age-related macular degeneration

关键词:  年龄相关性黄斑变性  杞黄颗粒  中医证候

Key words:  age-related macular degeneration (AMD)  Qihuang Particles  TCM syndrome

摘要:

[目的]观察杞黄颗粒治疗肝肾阴虚型年龄相关性黄斑变性的临床疗效。[方法]肝肾阴虚型年龄相关性黄斑变性干性、湿性患者共120例，随机分为杞黄颗粒治疗组62例、维生素C对照组58例，观察治疗前后视力及中医证候评分变化。[结果]视力方面：对年龄相关性黄斑变性（AMD）患者治疗组与对照组治疗前后的总体视力进行组间比较，差异无统计学意义（P>0.05）；对AMD患者治疗组与对照组治疗前后的总体视力进行组内比较，差异有统计学意义（P<0.05）；杞黄颗粒治疗组显效24例，有效36例，无效2例，总有效率为96.77%。维生素C对照组显效4例，有效31例，无效23例，总有效率为60.35%。治疗组中医证候的改善明显优于对照组，经秩和检验，两组治疗前后对比差异有统计学意义（P<0.05）。杞黄颗粒治疗组内干性共45例，显效19例，有效24例，无效2例，总有效率为95.56%；湿性共17例，显效5例，有效12例，无效0例，总有效率为100%。经秩和检验，干性与湿性对比结果差异无统计学意义（P>0.05）。[结论]杞黄颗粒和维生素C对肝肾阴虚型AMD患者的视力均有一定的改善作用；杞黄颗粒对AMD患者的中医证候改善作用明显，具有良好的临床疗效。

Abstract:

[Objective] To observe the clinical effects of Qihuang Particles in liver-kidney deficiency of age-related macular degeneration (AMD).[Methods] All dates were processed by rank sum test,by adopting a pre-and post-treatment pairing study,a total of 120 patients with dry and wet liver-kidney deficiency AMD were randomly divided into Qihuang Particles treatment group (62 cases) and VC control group (58 cases) in order to investigate score changes of vision and TCM syndrome.[Results] On the observe of vision:the differences of the overall vision between before and after treatment of the two groups are no statistically significant (P>0.05).But there are significant differences of the overall vision in the same group before and after contrast (P<0.05).On the observe of TCM syndrome:24 patients show an excellent effect in the Qihuang Particles treatment group,accounting for 38.71%;36 of effective,accounting for 58.06%,and 2 of ineffective,accounting for 3.23%,with an overall response rate (ORR) of 96.77%.Four patients show an excellent effect in the VC control group,accounting for 6.90%;31 of effective,accounting for 53.45%;and 23 of ineffective,accounting for 38.65%,with an ORR of 60.35%.The improvement of TCM syndrome in the treatment group is significantly superior to control group.The difference has statistical significance (P<0.05) compared to pre-and post-treatment between two groups via rank-sum test.Among 45 patients with dry type in the Qihuang Particles treatment group,19 patients show an excellent effect,accounting for 42.22%;24 of effective,accounting for 53.33%;2 of ineffective,accounting for 4.44%,with an ORR of 95.56% while among 17 patients with wet type,5 patients show an excellent effect,accounting for 29.41%;12 of effective,accounting for 70.59%;0 of ineffective,accounting for 0%,with an ORR of 100%.The difference has no statistical significance (P>0.05) compared to dry and wet type of patients via rank-sum test.[Conclusion] Qihuang granule and vitamin C on liver-kidney yin deficiency type of age-related macular degeneration patiengts of vision have a certain improving effect.Qihuang Particles can significantly improve the TCM syndrome in patients with AMD with an excellent clinical effect.