三维细胞微流控芯片模型的研究现状和在药物毒性评价中的应用进展

Research status of 3D cell microfluidic chip model and its application in drug toxicity evaluation

关键词:  3D细胞  微流控芯片  药物毒性评价  生物打印  类器官

Key words:  3D cell  microfluidic chip  drug toxicity evaluation  bioprinting  organoid

摘要:

目前用于临床前药物筛选和评价的传统细胞培养和动物模型存在不同程度的缺陷。三维细胞微流控芯片模型作为一种新型的体外研究模型，能够高度模拟人体组织的生理结构、功能，组织所处的生化和力学微环境，经长期培养保持组织功能稳定，因此在构建生理病理模型、药物筛选及再生医学等方面具有广阔前景。文章综述了三维细胞微流控芯片模型的研究进展，以药物毒性评价为重点讨论了其优势、可行性、中药应用实例和存在问题，并针对中药传承创新研究的特点展望了三维细胞微流控芯片模型的价值和广阔应用前景。

Abstract:

At present, the traditional cell culture and animal models used for pre-clinical drug screening and evaluation have different degrees of defects. Three-dimensional cell microfluidic chip model as a new research model in vitro, can simulate high tissue physiological structure, function, structure of biochemical and mechanical environment, maintain tissue function is stable, long-term training in physiological and pathological model was constructed, drug screening and regenerative medicine has broad prospects. In this paper, the research progress of 3D cell microfluidic chip model was reviewed. The advantages, feasibility, application cases and existing problems of 3D cell microfluidic chip model were discussed with drug toxicity evaluation as the focus, and the great value and broad application prospects of 3D cell microfluidic chip model were prospected according to the characteristics of traditional Chinese medicine inheritance and innovation research.