氧化石墨烯及其衍生物在中药有效成分应用方面的研究进展

Application of graphene oxide and its derivatives in active ingredients of traditional Chinese medicine：a review

关键词:  氧化石墨烯  衍生物  中药有效成分  提取分离  纳米递药系统  光热治疗

Key words:  graphene oxide  composite  active components of traditional Chinese medicine  extraction and separation  nano-drug delivery system  photothermal therapy

摘要:

中药有效成分普遍存在溶解性差、含量低且提取分离手段繁琐,不利于检测分析和成药性差等局限性,限制了其临床应用。氧化石墨烯等新型纳米材料凭借独特的物理化学性质逐渐被用于中药有效成分提取、分离纯化和抗肿瘤等,有望改善中药临床应用限制,促进中医药临床发展。作者从氧化石墨烯的结构性质出发,总结了其在中药有效成分方面的应用,包括促进中药有效成分溶出与提高分离纯化效率,改善生物利用度,增强成药性,提高抗肿瘤靶向性、缓释性、增强疗效等并对其中存在问题及未来发展进行讨论,旨在为氧化石墨烯及其衍生物在中医药领域的发展和中药有效成分在临床上的实际应用提供参考。

Abstract:

The active ingredients of traditional Chinese medicine (TCM) generally have poor solubility,low content,and cumbersome extraction and separation methods,which are not conducive to detection and analysis and poor medicinal properties,limiting their clinical application. New nanomaterials such as Graphene oxide (GO) have been gradually used in the extraction,separation and purification of active components of TCM and anti-tumor therapy due to their unique physicochemical properties,which are expected to improve the clinical application limitations of TCM and promote the clinical development of TCM. Based on the structural properties of GO,this paper summarizes the application of GO in the effective components of TCM,including promoting the dissolution of the effective components of TCM and improving the separation and purification efficiency,improving bioavailability,enhancing drug potency,improving tumor targeting,sustained release,and enhancing curative effect. The existing problems and future development of GO are discussed. The purpose of this study is to provide reference for the development of GO and its derivatives in the field of TCM and the clinical application of active components of TCM.