中药调控脂肪酸代谢重编程干预糖尿病肾病研究进展

Research progress of traditional Chinese medicine intervention in diabetic nephropathy based on fatty acid metabolic reprogramming

关键词:  糖尿病肾病  脂肪酸代谢  中药  研究进展

Key words:  diabetic nephropathy  fatty acid metabolism  traditional Chinese medicine  research progress

摘要:

糖尿病肾病（DN）是常见的糖尿病微血管并发症之一，同时也是终末期肾病的主要病因。近年来，中医药领域关于脂代谢与DN关系的研究热度逐年上涨，脂肪酸代谢是脂代谢中的重要环节，与DN的发生发展密切相关。中医药治疗DN具有悠久的历史以及良好的疗效，中药调节脂肪酸代谢的作用机制也不断被发现和揭示。文章论述了脂肪酸代谢失调与DN之间的联系，总结了靶向脂肪酸代谢重编程缓解DN的中医药方法，为深入研究DN脂肪酸代谢相关机制及寻找靶向干预手段提供思路，以期为DN的防治提供参考。

Abstract:

Diabetic nephropathy（DN） is one of the most common micro-vascular complications of diabetes. It is also the main risk factor of end-stage renal disease. In recent years，the research on the relationship between lipid metabolism and DN in the field of traditional Chinese medicine（TCM） has been increasing year by year. Fatty acid metabolism is an important link in lipid metabolism and is closely related to the occurrence and development of DN. The treatment of DN by TCM has a long history and good curative effect，and the mechanism of regulating fatty acid metabolism by TCM has been discovered and revealed. Therefore，this paper discusses the relationship between fatty acid metabolism disorders and DN，summarizes the TCM methods targeting fatty acid metabolism disorders to alleviate diabetic kidney disease，and provides references for further research on the relevant mechanism of DN fatty acid metabolism and searching for targeted intervention means，in order to provide a reference for the prevention and treatment of DN.