CiteSpace分析针灸治疗肿瘤动物实验研究的现状

Analysis of the current sesearch status of acupuncture in tumor animal experiments based on CiteSpace

关键词:  针灸  骨髓抑制  癌痛  免疫调节  CiteSpace

Key words:  acupuncture  myelosuppression  cancer pain  immune regulation  CiteSpace

摘要:

[目的] 探索针灸治疗肿瘤动物实验的研究热点和现状。[方法] 检索中国知网、万方、维普已发表的相关文献（建库至2024年3月20日）。运用CiteSpace绘制知识图谱，进行关键词共现、突现和聚类分析。[结果] 共纳入202篇文献，234个关键词。研究热点是针灸治疗肿瘤的并发症骨髓抑制和癌痛，未来趋势为免疫调节方面分子靶点和信号传导通路。骨髓抑制方面，发现针灸可以提高骨髓细胞DNA修复相关蛋白的表达，改善骨髓抑制。癌痛方面常用的干预方式是电针，参数为疏密波2/200 Hz，强度为低强度向高强度逐渐递增，研究方面主要在电针对癌痛小鼠神经调控和免疫调节方面。免疫调节方面常用的干预方式为艾灸，研究方向多集中在巨噬细胞、淋巴细胞、NK细胞方面，关于分子靶点、信号通路的研究较少。[结论] 应用CiteSpace分析针灸治疗肿瘤动物实验文献的关键词，得出现阶段的研究热点，以新颖的角度揭示了目前研究热点的现状，为从事该领域的研究者们提供可选择的研究方法，具有重要的价值和意义。

Abstract:

[Objective] To explore the research hotspots and current status of acupuncture in animal experiments for tumor therapy. [Methods] Relevant literature published up to March 20，2024，was retrieved from the CNKI，Wanfang，and VIP databases. CiteSpace software was used to generate knowledge maps and perform keyword co-occurrence，burst detection，and cluster analysis. [Results] A total of 202 articles and 234 keywords were included. The current research hotspots are acupuncture for managing tumor complications，specifically myelosuppression and cancer pain. Future trends are anticipated to focus on molecular targets and signaling pathways related to immune regulation. Regarding myelosuppression，acupuncture was found to enhance the expression of DNA repair-related proteins in bone marrow cells，thereby alleviating the condition. For cancer pain，electroacupuncture is the most common intervention，typically using a dense-disperse wave at 2/200 Hz with an intensity gradually increasing from low to high. Research in this area primarily focuses on the neural and immunomodulatory effects of electroacupuncture in mouse models of cancer pain. Moxibustion is the frequently used intervention for immune regulation，with studies concentrating on macrophages，lymphocytes，and NK cells. However，research on specific molecular targets and signaling pathways remains limited. [Conclusion] Utilizing CiteSpace to analyze keywords from the literature on acupuncture in tumor animal experiments effectively identified current research hotspots. This study offers a novel perspective on the field’s landscape，providing valuable insights and potential research methodologies for investigators in this area，thereby holding significant importance.