| 摘要: |
| 脉络舒通制剂由12味中药组成，具有清热解毒、化瘀通络、祛湿消肿的功效。研究发现，脉络舒通制剂含有249种成分，其中包括79种黄酮类、62种萜类、38种酚酸类、22种生物碱类、12种香豆素类、11种羧酸类、9种酯类、5种氨基酸类、3种苯酞类、2种酮类、2种醌类、2种二苯乙烯类、1种醛类和1种糖类成分，具有抗血栓性浅静脉炎、抗深静脉血栓、抗血栓闭塞性脉管炎、抗动脉粥样硬化、抗脑缺血再灌注损伤等药理作用。文章对脉络舒通制剂的化学成分及药理作用进行系统归纳总结，以期为其质量控制和深度开发利用提供参考。 |
| 关键词: 脉络舒通制剂 化学成分 药理作用 血栓性浅静脉炎 深静脉血栓 |
| DOI：10.11656/j.issn.1673-9043.2026.03.13 |
| 分类号:R285 |
| 基金项目:国家自然科学基金项目（81973557）。 |
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| Research progress on chemical constituents and pharmacological effects of Mailuoshutong preparation |
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LIU Yuhao1, ZHANG Lin1, LIU Mingfei1, XU Qianqian1, XIAO Xuefeng1, WANG Yuefei2
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1.School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China;2.Tianjin Key Laboratory of TCM Chemistry and Analysis, Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
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| Abstract: |
| Mailuoshutong（MLST） preparation is composed of twelve traditional Chinese medicinal materials，and it possesses the efficacy of clearing heat and toxins，resolving blood stasis and dredging collaterals，as well as removing dampness and relieving swelling. Research has identified 249 chemical constituents in MLST preparation，including 79 flavonoids，62 terpenoids，38 phenolic acids，22 alkaloids，12 coumarins，11 carboxylic acids，9 esters，5 amino acids，3 phthalides，2 ketones，2 quinones，2 stilbenes，1 aldehyde，and 1 saccharide. It demonstrates a range of pharmacological activities，such as those against superficial thrombophlebitis，deep venous thrombosis，thromboangiitis obliterans，atherosclerosis，and cerebral ischemia-reperfusion injury. This review systematically summarizes the chemical constituents and pharmacological effects of MLST preparation，aiming to provide references for its quality control and further development and utilization. |
| Key words: Mailuoshutong preparation chemical constituents pharmacological effects superficial thrombophlebitis deep venous thrombosis |
